Researchgate
Colorectal Cancer: On the Rise in Developing Nations
Global Burden and Trends
Colorectal cancer (CRC) has become a global health concern, ranking as the second most deadly cancer globally. Its incidence is particularly concerning in developing nations, where it is steadily rising.
Risk Factors
The causes of CRC are complex, involving both genetic and environmental factors. Genetic predispositions, such as Lynch syndrome and familial adenomatous polyposis, play a role. Environmental factors like diet, tobacco use, and obesity have also been linked to an increased risk.
Global Distribution
Globally, colon cancer is more prevalent than rectum cancer. In one study, colon cancer accounted for 59% of CRC cases and 61% of deaths, while rectum cancer made up 37% of cases.
Outlook and Future Projections
CRC remains a major cause of mortality, and its incidence and mortality rates are expected to increase in the coming decades. This trend is particularly worrisome in developing nations, where resources for early detection and treatment may be limited.
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